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Need Help on error 100 in MM Fusion 7.4.4

Have been running Mixmeister for years with no problems now I get error 100 message and program does not run MMFusion running Vista Home premium 64 bit...have searched the web trying everything out there with no success..was wondering if anyone had an answer on how to correct this as I am out of ideas....maybe Mixmeister has a fix?
error message here:
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